Millthorpe is situated in the heart of the South Bank area of York with the main entrance at the end of Nunthorpe Avenue off Scarcroft Road. There is a second entrance at the top of Philadelphia Terrace. This is open for all students to arrive and leave at the beginning and end of school but is kept locked during the school day.
Millthorpe is a five minute walk from Blossom street which has bus stops for most major routes including the number 1, 10 and 16 buses from Acomb and Holgate, number 4 and 12 buses from Foxwood and Woodthorpe and number 11 and 12 buses from Heworth and Haxby. The number 11 has stops in South Bank on Scarcroft Road, Bishopthorpe Road and Queen Victoria Street, all of which are a few minutes walk from Millthorpe.